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Kidney Failure

Kidney failure (renal failure) occurs when one or both kidneys lose their ability to function properly. It can develop rapidly (acute kidney failure) or over a long period (chronic kidney failure).

Stages of Kidney Failure

Normal Function

Mild loss of function

Moderate loss of function

Severe loss of function

Kidney Failure

Causes of Kidney Failure

  • Diabetes or High Blood Sugar
  • High Blood Pressure (Hypertension)
  • Polycystic Kidney Disease
  • Autoimmune Diseases (e.g., Lupus)
  • Chronic Glomerulonephritis (inflammation of the kidney’s filtering units)
  • Urinary Tract Obstruction
  • Medication Overuse and Toxins
  • Nephrotic Syndrome

Symptoms of Kidney Failure

Limitations of Medication Therapy

  • Dialysis Limitations:
  • Haemodialysis: Requires strict dietary restrictions (e.g., low sodium). Patients may experience fatigue, nausea, cramps, and low blood pressure. It doesn’t fully replicate kidney function.
  • Peritoneal Dialysis: Less effective at removing waste, with limited technique survival over time.
  • Angiotensin-Converting Enzyme (ACE) Inhibitors: Can cause low blood pressure, dizziness, or kidney dysfunction in some patients.
  • Prolonged use of diuretics or phosphate binders can lead to electrolyte imbalances or gastrointestinal issues.
  • Kidney Transplantation Limitations: Requires lifelong immunosuppressive medications to prevent organ rejection, increasing infection risk. 

Limited availability of donor kidneys leads to long waiting times for transplantation.

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